Vayne vs Karthus Counter Pick

Range decides the early exchanges. Karthus attacks from 450 units, a hundred short of 550, and the Deathsinger owns no dash or blink at 335 movement speed against 330. The 56.1% posted from 214 games logged on patch 16.13.1 is built in that window, before mage items arrive.

What each side actually threatens:

• Defile is an aura, so Karthus wants his opponent standing inside it — which is also where Silver Bolts completes its third stack fastest.
• Wall of Pain slows movement and strips magic resistance, converting a retreat into a chain of landed Lay Waste casts.
• Requiem ignores position entirely after a three-second channel, so a healthy scoreline late is not the same thing as safety.
• Death Defied keeps him casting after death, meaning killing him during an objective fight settles nothing immediately.

Karthus is the heavier champion at 620 health and 2,490 at level 18 against 550 and 2,301, but his 46 base attack damage is the lowest figure either side carries and contributes nothing outside abilities. His magic damage meets Vayne‘s 30 magic resistance while her physical output meets his 21 base armor, so neither defensive stat covers both directions. Final Hour adds attack damage and invisibility during Tumble, which makes the all-in one-sided once she arrives. Difficulty ratings read 7 and 8.